Catalog Number - 65508-05P

Zx Similars C8™ Octyl is a traditional reversed-phase HPLC stationary phase manufactured on high-purity Type-B spherical silica with a fully endcapped octyl (C8) bonded phase. Designed as a cost-effective alternative to Agilent Zorbax® C8 columns, it offers comparable chromatographic behavior for USP L7 methods while providing the moderate hydrophobic retention, reproducibility, and reliability expected from a conventional C8 stationary phase. Compared to C18 columns, C8 phases generally provide reduced retention and faster elution of hydrophobic analytes.

65508-05P is a 50 mm x 4.6 mm ID analytical column packed with 5 µm Zx Similars C8 particles. The short 50 mm length is optimized for rapid analyses, fast equilibration, and high-throughput workflows. The 5 µm particle size provides excellent robustness, broad method compatibility, and lower operating pressure than smaller particle columns, making it well suited for conventional HPLC systems. Typical operating flow rates are approximately 1.0–2.0 mL/min.

This USP L7 column is ideal for hydrophobic and neutral compounds when less retention is desired than a comparable C18 phase. Common applications include pharmaceutical analysis, long-chain fatty acid separations, quality control testing, and fast analytical methods requiring chromatographic behavior similar to Agilent Zorbax® C8 columns.

Key Benefits

• Type-B spherical silica stationary phase

• Suitable alternative for USP L7 methods

• Comparable selectivity to Agilent Zorbax® C8 columns

• Fast analysis with 50 mm column length

• Broad compatibility with conventional HPLC systems

• Lower operating pressure than smaller particle columns

• Lower retention than C18 columns

• End-capped C8 bonded phase

Typical Applications

• USP L7 methods

• Reversed-phase HPLC

• Pharmaceutical analysis

• Quality control testing

• Method development

• Long-chain fatty acid analysis

• Fast analytical separations

• Method transfer and validation

Specifications

• Product Type: HPLC Column

• Stationary Phase: Zx Similars C8 Octyl

• USP Classification: L7

• Particle Size: 5 µm

• Particle Type: Type-B Spherical Silica

• Bonded Phase: C8 (Octyl)

• Endcapped: Yes

• Column Dimensions: 4.6 mm ID x 50 mm

• Length: 50 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for reversed-phase chromatography

• Short column length provides rapid analyses

• Compatible with conventional HPLC systems

• Lower operating pressure than smaller particle columns

• Provides less retention than comparable C18 stationary phases

• Excellent alternative for many USP L7 methods

• Suitable for routine analytical workflows

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